Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.
Identifieur interne : 000434 ( Main/Exploration ); précédent : 000433; suivant : 000435Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.
Auteurs : Kim H Rslev-Petersen [Danemark] ; Merete Lund Hetland ; Peter Junker ; Jan P Denphant ; Torkell Ellingsen ; Palle Ahlquist ; Hanne Lindegaard ; Asta Linauskas ; Annette Schlemmer ; Mette Yde Dam ; Ib Hansen ; Hans Christian Horn ; Christian Gytz Ammitzb Ll ; Anette J Rgensen ; Sophine B. Krintel ; Johnny Raun ; Julia S. Johansen ; Mikkel Stergaard ; Kristian Stengaard-PedersenSource :
- Annals of the rheumatic diseases ; 2014.
English descriptors
- KwdEn :
- Adalimumab, Adult, Aged, Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (administration & dosage), Antirheumatic Agents (adverse effects), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (physiopathology), Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Injections, Intra-Articular, Male, Methotrexate (administration & dosage), Methotrexate (adverse effects), Methotrexate (therapeutic use), Middle Aged, Quality of Life, Remission Induction, Severity of Illness Index, Treatment Outcome, Triamcinolone (administration & dosage), Triamcinolone (adverse effects), Triamcinolone (therapeutic use).
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate, Triamcinolone.
- chemical , adverse effects : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate, Triamcinolone.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate, Triamcinolone.
- chemical : Adalimumab.
- drug therapy : Arthritis, Rheumatoid.
- physiopathology : Arthritis, Rheumatoid.
- Adult, Aged, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Injections, Intra-Articular, Male, Middle Aged, Quality of Life, Remission Induction, Severity of Illness Index, Treatment Outcome.
Abstract
An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity (DAS28CRP<3.2) at 12 months.
DOI: 10.1136/annrheumdis-2012-202735
PubMed: 23434570
Affiliations:
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Le document en format XML
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The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.</title><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name></author><author><name sortKey="Ahlquist, Palle" sort="Ahlquist, Palle" uniqKey="Ahlquist P" first="Palle" last="Ahlquist">Palle Ahlquist</name></author><author><name sortKey="Lindegaard, Hanne" sort="Lindegaard, Hanne" uniqKey="Lindegaard H" first="Hanne" last="Lindegaard">Hanne Lindegaard</name></author><author><name sortKey="Linauskas, Asta" sort="Linauskas, Asta" uniqKey="Linauskas A" first="Asta" last="Linauskas">Asta Linauskas</name></author><author><name sortKey="Schlemmer, Annette" sort="Schlemmer, Annette" uniqKey="Schlemmer A" first="Annette" last="Schlemmer">Annette Schlemmer</name></author><author><name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name></author><author><name sortKey="Hansen, Ib" sort="Hansen, Ib" uniqKey="Hansen I" first="Ib" last="Hansen">Ib Hansen</name></author><author><name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name></author><author><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name></author><author><name sortKey="J Rgensen, Anette" sort="J Rgensen, Anette" uniqKey="J Rgensen A" first="Anette" last="J Rgensen">Anette J Rgensen</name></author><author><name sortKey="Krintel, Sophine B" sort="Krintel, Sophine B" uniqKey="Krintel S" first="Sophine B" last="Krintel">Sophine B. Krintel</name></author><author><name sortKey="Raun, Johnny" sort="Raun, Johnny" uniqKey="Raun J" first="Johnny" last="Raun">Johnny Raun</name></author><author><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23434570</idno><idno type="pmid">23434570</idno><idno type="doi">10.1136/annrheumdis-2012-202735</idno><idno type="wicri:Area/PubMed/Corpus">000240</idno><idno type="wicri:Area/PubMed/Curation">000240</idno><idno type="wicri:Area/PubMed/Checkpoint">000192</idno><idno type="wicri:Area/Ncbi/Merge">000A47</idno><idno type="wicri:Area/Ncbi/Curation">000A47</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A47</idno><idno type="wicri:Area/Main/Merge">000423</idno><idno type="wicri:Area/Main/Curation">000434</idno><idno type="wicri:Area/Main/Exploration">000434</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.</title><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name></author><author><name sortKey="Ahlquist, Palle" sort="Ahlquist, Palle" uniqKey="Ahlquist P" first="Palle" last="Ahlquist">Palle Ahlquist</name></author><author><name sortKey="Lindegaard, Hanne" sort="Lindegaard, Hanne" uniqKey="Lindegaard H" first="Hanne" last="Lindegaard">Hanne Lindegaard</name></author><author><name sortKey="Linauskas, Asta" sort="Linauskas, Asta" uniqKey="Linauskas A" first="Asta" last="Linauskas">Asta Linauskas</name></author><author><name sortKey="Schlemmer, Annette" sort="Schlemmer, Annette" uniqKey="Schlemmer A" first="Annette" last="Schlemmer">Annette Schlemmer</name></author><author><name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name></author><author><name sortKey="Hansen, Ib" sort="Hansen, Ib" uniqKey="Hansen I" first="Ib" last="Hansen">Ib Hansen</name></author><author><name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name></author><author><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name></author><author><name sortKey="J Rgensen, Anette" sort="J Rgensen, Anette" uniqKey="J Rgensen A" first="Anette" last="J Rgensen">Anette J Rgensen</name></author><author><name sortKey="Krintel, Sophine B" sort="Krintel, Sophine B" uniqKey="Krintel S" first="Sophine B" last="Krintel">Sophine B. Krintel</name></author><author><name sortKey="Raun, Johnny" sort="Raun, Johnny" uniqKey="Raun J" first="Johnny" last="Raun">Johnny Raun</name></author><author><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="e-ISSN">1468-2060</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adalimumab</term><term>Adult</term><term>Aged</term><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antibodies, Monoclonal, Humanized (adverse effects)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Antirheumatic Agents (administration & dosage)</term><term>Antirheumatic Agents (adverse effects)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (physiopathology)</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Intra-Articular</term><term>Male</term><term>Methotrexate (administration & dosage)</term><term>Methotrexate (adverse effects)</term><term>Methotrexate (therapeutic use)</term><term>Middle Aged</term><term>Quality of Life</term><term>Remission Induction</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Triamcinolone (administration & dosage)</term><term>Triamcinolone (adverse effects)</term><term>Triamcinolone (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term><term>Triamcinolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term><term>Triamcinolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term><term>Triamcinolone</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adalimumab</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Intra-Articular</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Remission Induction</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity (DAS28CRP<3.2) at 12 months.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><noCountry><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><name sortKey="Ahlquist, Palle" sort="Ahlquist, Palle" uniqKey="Ahlquist P" first="Palle" last="Ahlquist">Palle Ahlquist</name><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name><name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name><name sortKey="Hansen, Ib" sort="Hansen, Ib" uniqKey="Hansen I" first="Ib" last="Hansen">Ib Hansen</name><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name><name sortKey="J Rgensen, Anette" sort="J Rgensen, Anette" uniqKey="J Rgensen A" first="Anette" last="J Rgensen">Anette J Rgensen</name><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><name sortKey="Krintel, Sophine B" sort="Krintel, Sophine B" uniqKey="Krintel S" first="Sophine B" last="Krintel">Sophine B. Krintel</name><name sortKey="Linauskas, Asta" sort="Linauskas, Asta" uniqKey="Linauskas A" first="Asta" last="Linauskas">Asta Linauskas</name><name sortKey="Lindegaard, Hanne" sort="Lindegaard, Hanne" uniqKey="Lindegaard H" first="Hanne" last="Lindegaard">Hanne Lindegaard</name><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name><name sortKey="Raun, Johnny" sort="Raun, Johnny" uniqKey="Raun J" first="Johnny" last="Raun">Johnny Raun</name><name sortKey="Schlemmer, Annette" sort="Schlemmer, Annette" uniqKey="Schlemmer A" first="Annette" last="Schlemmer">Annette Schlemmer</name><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></noCountry><country name="Danemark"><noRegion><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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